Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S3XI
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| Former ID |
DIB020389
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| Drug Name |
monomethylfumarate
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| Synonyms |
Monomethyl fumarate; 2756-87-8; 4-methoxy-4-oxobut-2-enoic acid; Methyl hydrogen fumarate; mono-Methyl fumarate; (E)-4-methoxy-4-oxobut-2-enoic acid; Fumaric acid monomethyl ester; UNII-45IUB1PX8R; 45IUB1PX8R; CHEMBL589586; NKHAVTQWNUWKEO-NSCUHMNNSA-N; AK114632; (2E)-3-(methoxycarbonyl)prop-2-enoic acid; (E)-4-methoxy-4-oxobut-2-enoic acid(98%); 44836-34-2; EINECS 220-412-6; Fumaric acid 1-methyl; AC1NSSIL; Monomethyl fumarate [USAN]; mono-Methyl fumarate, 97%; SCHEMBL60132; SCHEMBL60133; GTPL5786; AC1Q5T88; MolPort-002-472-973
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C5H5O4-
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| Canonical SMILES |
COC(=O)C=CC(=O)[O-]
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| InChI |
1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/p-1/b3-2+
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| InChIKey |
NKHAVTQWNUWKEO-NSCUHMNNSA-M
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11656144, 14747649, 24883828, 39389755, 57362341, 79686239, 85245433, 90417319, 103724331, 114166309, 117544853, 118313549, 126551303, 131345362, 135060089, 136992887, 137202212, 137251158, 142653492, 143438467, 144107207, 152032061, 162077181, 162183081, 163413037, 164811949, 164841619, 172892108, 175267099, 178102411, 204371895, 223349343, 223560257, 224361589, 226442098, 226442099, 241058095, 244277959, 248094066, 249848971, 249965991, 252035329, 252158126, 252410803
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nicotinic acid receptor (HCAR2) | Target Info | Agonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5786). | |||
| REF 2 | The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. | |||
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