Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S4NO
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| Former ID |
DNC009402
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| Drug Name |
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide
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| Synonyms |
CHEMBL500977; 30457-35-3; N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide; CTK8I1084; ZINC39121736; BDBM50256510; AKOS027393952; KB-299693; N-(5-ethyl-1,3,4-thiadiazol-2-yl)aminosulfonamide; N-(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfuric diamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C4H8N4O2S2
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| Canonical SMILES |
CCC1=NN=C(S1)NS(=O)(=O)N
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| InChI |
1S/C4H8N4O2S2/c1-2-3-6-7-4(11-3)8-12(5,9)10/h2H2,1H3,(H,7,8)(H2,5,9,10)
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| InChIKey |
HVRGNGCSIVHKLU-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carbonic anhydrase (CA) | Target Info | Inhibitor | [1] |
| Carbonic anhydrase I (CA-I) | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase II (CA-II) | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase IV (CA-IV) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Nitrogen metabolism | |||
| Proximal tubule bicarbonate reclamation | ||||
| Collecting duct acid secretion | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| EGFR1 Signaling Pathway | ||||
| Pathwhiz Pathway | Gastric Acid Production | |||
| Pathway Interaction Database | C-MYB transcription factor network | |||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | |||
| Erythrocytes take up oxygen and release carbon dioxide | ||||
| Reversible hydration of carbon dioxide | ||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | |||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | ||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. | |||
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