Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S5CU
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| Former ID |
DAP000595
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| Drug Name |
Nisoldipine
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| Synonyms |
Baymycard; Nisocor; Nisoldipin; Nisoldipino; Nisoldipinum; Sular; Syscor; Zadipina; Bay k 5552; Nisoldipino [INN-Spanish]; Nisoldipinum [INN-Latin]; Sular (TN); Bay-k-5552; Nisoldipine (JAN/USAN/INN); Nisoldipine [USAN:BAN:INN:JAN]; Isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridincarboxylat;Methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (+-)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester; 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
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Download2D MOL |
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| Formula |
C20H24N2O6
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| Canonical SMILES |
CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
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| InChI |
1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
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| InChIKey |
VKQFCGNPDRICFG-UHFFFAOYSA-N
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| CAS Number |
CAS 63675-72-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9901, 5054384, 6595685, 6951250, 7594280, 7847684, 7980129, 8152772, 11528722, 12012773, 14780577, 26719878, 26758055, 29223593, 46386699, 46504546, 48416330, 49681768, 53787999, 56313694, 56463094, 57322301, 80626920, 81092916, 92307945, 92308528, 92308896, 92711446, 93166842, 103219831, 103680984, 104306583, 117875317, 118048486, 121363368, 124658895, 124799896, 125355226, 126630843, 126657331, 126665640, 131322121, 131846259, 134337886, 135004762, 135650722, 135692260, 137122027, 137349418, 139157574
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| ChEBI ID |
CHEBI:76917
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| ADReCS Drug ID | BADD_D01570 | |||
| SuperDrug ATC ID |
C08CA07
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| SuperDrug CAS ID |
cas=063675729
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Blocker | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2524). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 079051. | |||
| REF 3 | RT-PCR and pharmacological analysis of L-and T-type calcium channels in rat carotid body. Adv Exp Med Biol. 2009;648:105-12. | |||
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