Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S6HI
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| Former ID |
DIB018875
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| Drug Name |
arcaine
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| Synonyms |
arcaine; Tetramethylenediguanide; 1,4-Diguanidinobutane; N,N'''-1,4-Butanediylbisguanidine; Arcain; 544-05-8; 1-(4-guanidinobutyl)guanidine; CHEMBL102740; CHEBI:16652; 1,1'-(butane-1,4-diyl)diguanidine; Guanidine, N,N'''-1,4-butanediylbis-; A-8340; 1-(4-carbamimidamidobutyl)guanidine; 58585-47-0; 2,2'-butane-1,4-diyldiguanidine; Tocris-0389; Spectrum_001819; Prestwick2_000876; Spectrum5_001638; Prestwick1_000876; Prestwick0_000876; Spectrum3_001100; Spectrum2_000601; Prestwick3_000876; Spectrum4_001929; Lopac-A-0384
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C6H16N6
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| Canonical SMILES |
C(CCN=C(N)N)CN=C(N)N
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| InChI |
1S/C6H16N6/c7-5(8)11-3-1-2-4-12-6(9)10/h1-4H2,(H4,7,8,11)(H4,9,10,12)
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| InChIKey |
HGMDNMBBCKDWTQ-UHFFFAOYSA-N
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| CAS Number |
CAS 544-05-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5950, 4652564, 8144961, 11110706, 11110707, 11113479, 11335530, 11360769, 11364731, 11367293, 11369855, 11372099, 11375416, 11378019, 11461741, 11466904, 11468024, 11484238, 11486608, 11488417, 11490915, 11493743, 11495633, 11537581, 16935909, 26751697, 29221403, 47216701, 47291053, 47365108, 47365109, 47440173, 47588914, 47736395, 47885329, 48035025, 48035026, 49698961, 49746786, 49974340, 50104389, 57321211, 77714661, 90341645, 103108087, 103321883, 103940979, 104299979, 117516622, 124749415
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| ChEBI ID |
CHEBI:16652
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acid-sensing ion channel 3 (ASIC3) | Target Info | Activator | [2] |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Reactome | Stimuli-sensing channels | |||
| WikiPathways | Iron uptake and transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4137). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 686). | |||
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