Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S6SN
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| Former ID |
DIB018678
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| Drug Name |
6-hydroxymelatonin
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| Synonyms |
6-OH-MLT; 6-OH-melatonin
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C13H16N2O3
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| Canonical SMILES |
CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)O
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| InChI |
1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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| InChIKey |
OMYMRCXOJJZYKE-UHFFFAOYSA-N
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| CAS Number |
CAS 2208-41-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7954, 893936, 6755094, 8151317, 11111254, 15246386, 17405174, 24278458, 29221059, 46500364, 47440487, 47810987, 47885611, 48185191, 48259464, 49747735, 49859680, 50106421, 50106422, 53777718, 57321050, 76900860, 85086806, 85229955, 85231069, 87692435, 90341208, 92297621, 92303802, 93576058, 103357373, 104298938, 121361350, 124749857, 124799820, 124880276, 125660570, 126524998, 128832333, 134982536, 135649850, 136350480, 137188864, 137242412, 144233494, 162090920, 163132057, 163564566, 164174528, 164842634
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| ChEBI ID |
CHEBI:2198
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melatonin receptor type 1A (MTNR1A) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Circadian entrainment | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1347). | |||
| REF 2 | Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther. 1985 Aug;234(2):395-401. | |||
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