Drug Information
Drug General Information | Top | |||
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Drug ID |
D0S6SQ
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Former ID |
DIB014666
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Drug Name |
Odelepran
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Synonyms |
Odelepran hydrochloride; LY2196044 HCl; LY-2196044; OpRA (alcohol dependence), Eli Lilly; OpRA II (alcoholism), Eli Lilly; Opioid receptor antagonist (alcoholism), Eli Lilly
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Drug Type |
Small molecular drug
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Indication | Alcohol dependence [ICD-11: 6C40.2; ICD-10: F10.2; ICD-9: 303] | Phase 2 | [1] | |
Company |
Eli Lilly & Co
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Structure |
Download2D MOL |
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Formula |
C20H24FN3O3
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Canonical SMILES |
C1COCCC1CCNCC2=CC(=C(C=C2)OC3=NC=C(C=C3)C(=O)N)F
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InChI |
1S/C20H24FN3O3/c21-17-11-15(12-23-8-5-14-6-9-26-10-7-14)1-3-18(17)27-19-4-2-16(13-24-19)20(22)25/h1-4,11,13-14,23H,5-10,12H2,(H2,22,25)
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InChIKey |
QWNDOCKIKKQJNN-UHFFFAOYSA-N
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CAS Number |
CAS 676501-25-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Opioid receptor (OPR) | Target Info | Antagonist | [2] |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00804570) A Study for the Treatment of Alcohol Dependence.. U.S. National Institutes of Health. | |||
REF 2 | A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence. Alcohol Clin Exp Res. 2014 Feb;38(2):511-20. |
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