Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S7DV
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| Former ID |
DAP001433
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| Drug Name |
Tiazofurin
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| Synonyms |
Riboxamide; TCAR; TIZ; Tiazofurina; Tiazofurine; Tiazofurinum; Tiazole; Tiazofurin [USAN]; Tiazofurina [Spanish]; Tiazofurinum [Latin]; Cpd-5825; Tiazofurin (USAN); Tiazofurine (INN); 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide; 2-beta-D-Ribofuranosyl-4-thiazolecarboxamide; 2-ribofuranosylthiazole-4-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Approved | [1] | |
| Therapeutic Class |
Anticancer Agents
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| Structure |
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Download2D MOL |
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| Formula |
C9H12N2O5S
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| Canonical SMILES |
C1=C(N=C(S1)C2C(C(C(O2)CO)O)O)C(=O)N
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| InChI |
1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1
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| InChIKey |
FVRDYQYEVDDKCR-DBRKOABJSA-N
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| CAS Number |
CAS 60084-10-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
606015, 10302570, 12012976, 14823734, 14872336, 24770760, 26737438, 47207788, 50051787, 57405484, 74610381, 103328095, 109722895, 127340579, 127340580, 127906342, 134222062, 134338637, 135006424, 137156918, 137242660, 140152998, 143013889, 160847159, 162224190, 163411145, 163849160, 164765593, 179117146, 198978476, 223558181, 225050731, 225380230, 226396315, 241109682, 249859445, 250214917, 252075587, 252423709, 252510318
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| ChEBI ID |
CHEBI:90239
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| SuperDrug ATC ID |
L01XX18
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| SuperDrug CAS ID |
cas=060084108
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) | Target Info | Inhibitor | [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3167-70. | |||
| REF 2 | In vitro and in vivo antiproliferative activity of IPCAR, a new pyrazole nucleoside analog. Anticancer Res. 1998 Jul-Aug;18(4A):2623-30. | |||
| REF 3 | Sequential impact of tiazofurin and ribavirin on the enzymic program of the bone marrow. Cancer Res. 1993 Dec 15;53(24):5982-6. | |||
| REF 4 | Relationships between the cytotoxicity of tiazofurin and its metabolism by cultured human lung cancer cells. J Clin Invest. 1985 Jan;75(1):175-82. | |||
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