Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SB6K
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| Former ID |
DIB008992
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| Drug Name |
DAT-582
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| Synonyms |
AS-5820
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| Drug Type |
Small molecular drug
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| Indication | Nausea [ICD-11: MD90; ICD-10: R11] | Discontinued in Phase 2 | [1] | |
| Company |
Dainippon Pharmaceutical Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C22H29Cl2N5O
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| Canonical SMILES |
CC1=CC(=CC=C1)CN2CCN(CC(C2)NC(=O)C3=NNC4=CC=CC=C43)C.Cl.Cl
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| InChI |
1S/C22H27N5O.2ClH/c1-16-6-5-7-17(12-16)13-27-11-10-26(2)14-18(15-27)23-22(28)21-19-8-3-4-9-20(19)24-25-21;;/h3-9,12,18H,10-11,13-15H2,1-2H3,(H,23,28)(H,24,25);2*1H/t18-;;/m1../s1
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| InChIKey |
BDHAPQXDDJQQBI-JPKZNVRTSA-N
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| CAS Number |
CAS 141034-42-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3 receptor (5HT3R) | Target Info | Antagonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001226) | |||
| REF 2 | 5-HT3 receptor antagonist effects of DAT-582, (R) enantiomer of AS-5370. Eur J Pharmacol. 1992 Jun 17;216(3):435-40. | |||
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