Drug Information
Drug General Information | Top | |||
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Drug ID |
D0SZ1G
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Drug Name |
AZD9567
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Synonyms |
ZQFNDBISEYQVRR-LOSJGSFVSA-N; AZD-9567; GTPL9812; SCHEMBL17643955; AZD 9567; example 1 [WO2016046260A1]; compound 15 [PMID: 29424542]; B9W; 2,2-difluoro-N-[(1R,2S)-3-methyl-1-[1-(1-methyl-6-oxopyridin-3-yl)indazol-5-yl]oxy-1-phenylbutan-2-yl]propanamide; 2,2-bis(fluoranyl)-~{N}-[(1~{R},2~{S})-3-methyl-1-[1-(1-methyl-6-oxidanylidene-pyridin-3-yl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]propanamide
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Indication | Rheumatoid arthritis [ICD-11: FA20] | Phase 1 | [1] | |
Company |
AstraZeneca Wilmington, DE
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Structure |
Download2D MOL |
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Formula |
C27H28F2N4O3
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Canonical SMILES |
CC(C)C(C(C1=CC=CC=C1)OC2=CC3=C(C=C2)N(N=C3)C4=CN(C(=O)C=C4)C)NC(=O)C(C)(F)F
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InChI |
1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1
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InChIKey |
ZQFNDBISEYQVRR-LOSJGSFVSA-N
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CAS Number |
CAS 1893415-00-3
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Glucocorticoid receptor messenger RNA (GCR mRNA) | Target Info | Modulator | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
NetPath Pathway | IL2 Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Signaling events mediated by HDAC Class II | ||||
FOXA2 and FOXA3 transcription factor networks | ||||
Glucocorticoid receptor regulatory network | ||||
Regulation of Androgen receptor activity | ||||
AP-1 transcription factor network | ||||
Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
SIDS Susceptibility Pathways | ||||
Endoderm Differentiation | ||||
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
Adipogenesis | ||||
Circadian Clock | ||||
Nuclear Receptors |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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