Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T1OG
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| Former ID |
DNC012161
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| Drug Name |
N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine
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| Synonyms |
CHEMBL539413; SCHEMBL7125185
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C10H13N3O3S
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| Canonical SMILES |
CC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N=C(N)N
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| InChI |
1S/C10H13N3O3S/c1-6-3-4-7(17(2,15)16)5-8(6)9(14)13-10(11)12/h3-5H,1-2H3,(H4,11,12,13,14)
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| InChIKey |
SSLQVRLYNHXNIS-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium/hydrogen exchanger 1 (SLC9A1) | Target Info | Inhibitor | [1] |
| Sodium/hydrogen exchanger 3 (SLC9A3) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Cardiac muscle contraction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Regulation of actin cytoskeleton | ||||
| Thyroid hormone signaling pathway | ||||
| Salivary secretion | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| Proteoglycans in cancer | ||||
| Proximal tubule bicarbonate reclamation | ||||
| Protein digestion and absorption | ||||
| Mineral absorption | ||||
| Pathway Interaction Database | Endothelins | |||
| RhoA signaling pathway | ||||
| ErbB1 downstream signaling | ||||
| Signaling mediated by p38-alpha and p38-beta | ||||
| Reactome | Hyaluronan uptake and degradation | |||
| WikiPathways | Regulation of Actin Cytoskeleton | |||
| G Protein Signaling Pathways | ||||
| Glycosaminoglycan metabolism | ||||
| Osteoclast Signaling | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. | |||
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