Drug Information
Drug General Information | Top | |||
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Drug ID |
D0T2LN
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Drug Name |
Thiazole derivative 2
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Synonyms |
PMID28454500-Compound-83
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Drug Type |
Small molecular drug
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Company |
THE JOHNS HOPKINS UNIVERSITY The National Institutes of Health
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Structure |
Download2D MOL |
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Formula |
C22H14F3N3O4S
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Canonical SMILES |
C1=CC(=CC(=C1)[N+](=O)[O-])C2=CC=C(O2)C(=O)NC3=NC=C(S3)CC4=CC=C(C=C4)C(F)(F)F
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InChI |
1S/C22H14F3N3O4S/c23-22(24,25)15-6-4-13(5-7-15)10-17-12-26-21(33-17)27-20(29)19-9-8-18(32-19)14-2-1-3-16(11-14)28(30)31/h1-9,11-12H,10H2,(H,26,27,29)
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InChIKey |
GIUVRWFYNOIRLR-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target Info | Inhibitor | [1] |
Target's Patent Info | Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target's Patent Info | [1] | |
KEGG Pathway | Protein processing in endoplasmic reticulum | |||
NetPath Pathway | IL5 Signaling Pathway | |||
WikiPathways | Oxidative Stress | |||
Transcriptional activation by NRF2 | ||||
NRF2 pathway | ||||
Nuclear Receptors Meta-Pathway | ||||
Aryl Hydrocarbon Receptor Pathway | ||||
Mesodermal Commitment Pathway | ||||
Aryl Hydrocarbon Receptor | ||||
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | ||||
Arylhydrocarbon receptor (AhR) signaling pathway |
References | Top | |||
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REF 1 | Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. |
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