Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T3HY
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| Former ID |
DAP000268
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| Drug Name |
Levorphanol
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| Synonyms |
levorphanol; Levorphan; Methorphinan; Aromarone; Racemethorphanum; Dromoran; Cetarin; Antalgin; Levo-Dromoran; Racemic dromoran; Methorfinan [Czech]; Levorfanolo [DCIT]; Levorphanolum; Levorfanol; Orphan; Levorfanol [INN-Spanish]; Levorphanolum [INN-Latin]; Racemorfano [INN-Spanish]; 17-Methylmorphinan-3-ol; N-Methyl-3-hydroxymorphinan; Racemorphan; Racemorphan [INN:BAN]; Racemorphane [INN-French]; Racemorphanum [INN-Latin]; (-)-N-Methylmorphinan-3-ol; Morphinan-3-ol, 17-methyl-; Levorphanal; dl-3-Hydroxy-N-methylmorphinan; DEA No; Antalgin; DEXTRORPHAN; Levodroman; Levorfanolo; Methorfinan; Racemorfano; Racemorphane; Racemorphanum; NU 2206; L-Dromoran; Levorphanol (INN); Ro 1-5431; Levo-Dromoran (TN); Dl-3-Hydroxy-N-methylmorphinan; (+)-3-Hydroxy-17-methylmorphinan; (+-)-17-Methylmorphinan-3-ol; (+-)-3-Hydroxy-N-methylmorphinan; (-)-3-Hydroxy-N-methylmorphinan; 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, dl-mixture; 1,3,4,9,10,10a-Hexahydro-6-hydroxy-2H-10,4a-(iminoethano)-11-methylphenanthrene; 3-Hydroxy-N-methylmorphinan; Dextrorphan
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Approved | [1] | |
| Ischemic stroke [ICD-11: 8B11.5Z; ICD-9: 434.91] | Terminated | [2] | ||
| Therapeutic Class |
Analgesics
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| Company |
Roxane Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H23NO
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| Canonical SMILES |
CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)O
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| InChI |
1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
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| InChIKey |
JAQUASYNZVUNQP-USXIJHARSA-N
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| CAS Number |
CAS 297-90-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10214, 15020649, 24724648, 32961206, 46506558, 48416172, 49992831, 49993032, 57362766, 76028106, 96024813, 103928501, 123085530, 128247583, 134223222, 134337582, 134339944, 134972148, 135017293, 136350398, 137004972, 142097602, 160848620, 160964195, 175266678, 179116756, 198937435, 223365930, 223440165, 224186944, 226412710, 250137238, 252351126
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| ChEBI ID |
CHEBI:6444
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| ADReCS Drug ID | BADD_D01282 ; BADD_D01283 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | N-methyl-D-aspartate receptor (NMDAR) | Target Info | Antagonist | [3] |
| Opioid receptor (OPR) | Target Info | Agonist | [4] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009336) | |||
| REF 3 | Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2003 Jan;3(1):9-20. | |||
| REF 4 | Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis. J Pharmacol Exp Ther. 2004 May;309(2):515-22. | |||
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