Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T3TZ
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| Drug Name |
Benzimidazole derivative 6
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| Synonyms |
PMID28270010-Compound-Figure7-1
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Patented | [1] | |
| Company |
TESARO, INCAMGEN INC. BOEZIO, Christiane M. CHENG, Alan, C. CHOQUETTE, Deborah LEWIS, Richard, T. POTASHMAN, Michele, H. ROMERO, Karina STELLWAGEN, John, C. WHITTINGTON, Douglas, A
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| Structure |
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Download2D MOL |
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| Formula |
C33H44FN5O3
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| Canonical SMILES |
CC(C)NC(=O)C1CCC(CC1)N2C3=C(C=CC(=C3)CN4CCC(CC4)C(C)(C)O)N=C2NC(=O)C5=CC=C(C=C5)F
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| InChI |
1S/C33H44FN5O3/c1-21(2)35-30(40)24-8-12-27(13-9-24)39-29-19-22(20-38-17-15-25(16-18-38)33(3,4)42)5-14-28(29)36-32(39)37-31(41)23-6-10-26(34)11-7-23/h5-7,10-11,14,19,21,24-25,27,42H,8-9,12-13,15-18,20H2,1-4H3,(H,35,40)(H,36,37,41)
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| InChIKey |
WSTUJEXAPHIEIM-UHFFFAOYSA-N
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| CAS Number |
CAS 1357920-84-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ALK tyrosine kinase receptor (ALK) | Target Info | Inhibitor | [1] |
| Tropomyosin-related kinase A (TrkA) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | ALK tyrosine kinase receptor (ALK) | Target's Patent Info | [1] | |
| Tropomyosin-related kinase A (TrkA) | Target's Patent Info | [1] | ||
| KEGG Pathway | MAPK signaling pathway | |||
| Endocytosis | ||||
| Apoptosis | ||||
| Neurotrophin signaling pathway | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Pathways in cancer | ||||
| Transcriptional misregulation in cancer | ||||
| Thyroid cancer | ||||
| Central carbon metabolism in cancer | ||||
| Non-small cell lung cancer | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Neurotrophic factor-mediated Trk receptor signaling | |||
| Reactome | Frs2-mediated activation | |||
| ARMS-mediated activation | ||||
| NGF-independant TRKA activation | ||||
| PI3K/AKT activation | ||||
| WikiPathways | MAPK Signaling Pathway | |||
| BDNF signaling pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| Differentiation Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. | |||
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