Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T5SZ
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| Former ID |
DIB000349
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| Drug Name |
PNU-142721
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| Synonyms |
PNU-109866; PNU-142721E
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| Drug Type |
Small molecular drug
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Discontinued in Phase 1 | [1] | |
| Company |
Pharmacia & Upjohn Inc
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| Structure |
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Download2D MOL |
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| Formula |
C13H11ClN4OS
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| Canonical SMILES |
CC(C1=NC=C2C(=C1)C=CO2)SC3=NC(=CC(=N3)Cl)N
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| InChI |
1S/C13H11ClN4OS/c1-7(20-13-17-11(14)5-12(15)18-13)9-4-8-2-3-19-10(8)6-16-9/h2-7H,1H3,(H2,15,17,18)/t7-/m0/s1
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| InChIKey |
ATCRIOJPQXDFNY-ZETCQYMHSA-N
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| CAS Number |
CAS 185220-03-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010327) | |||
| REF 2 | Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci. 2011 Oct;20(10):1713-9. | |||
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