Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T6SC
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| Former ID |
DIB020545
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| Drug Name |
N-methylhistamine
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| Synonyms |
Nalpha-Methylhistamine dihydrochloride; NAMH dihydrochloride; 16503-22-3; N-Methylhistamine dihydrochloride; UNII-S6S98U0517; S6S98U0517; n-alpha-methylhistamine dihydrochloride; N(alpha)-methylhistamine HCl; SCHEMBL614543; 1H-Imidazole-4-ethanamine, N-methyl-, dihydrochloride; Imidazole, 4-(2-(methylamino)ethyl)-, dihydrochloride; CTK8G1926; CTK8G1225; DTXSID90167838
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C6H13Cl2N3
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| Canonical SMILES |
CNCCC1=CN=CN1.Cl.Cl
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| InChI |
1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
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| InChIKey |
AYUQICXJAMPXPF-UHFFFAOYSA-N
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| CAS Number |
CAS 16503-22-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7548, 111689, 5065180, 8145147, 8152280, 11111463, 15119885, 29222739, 47216971, 47810959, 48035337, 49979067, 50111134, 57321898, 76044006, 85209553, 90341373, 92298650, 103101425, 103173361, 104304019, 117477866, 117520177, 124749973, 124880726, 125676784, 126523660, 127848575, 132633463, 134223963, 134978378, 135650397, 135650399, 137099432, 141970489, 162860538, 164793246, 179235711, 198946623, 223789805, 226554786, 229808748, 249963036
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Agonist | [2] |
| Histamine H4 receptor (H4R) | Target Info | Agonist | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCR ligand binding | |||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1242). | |||
| REF 2 | Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. | |||
| REF 3 | Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30. | |||
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