Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0TJ2L
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| Former ID |
DNC011726
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| Drug Name |
RO-147437
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| Synonyms |
Ro-14-7437; CHEMBL267665; 78756-03-3; 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 5,6-dihydro-5-methyl-6-oxo-, ethyl ester; Ro 14-7437; RO-147437; AC1L2SAK; AC1Q6FI4; SCHEMBL7327790; CTK8D4431; HNGRWUCKESPKRC-UHFFFAOYSA-N; BDBM50034831; ethyl 5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]-benzodiazepine-3-carboxylate; ethyl 5,6-dihydro-5-methyl-6-oxo-4-H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; ethyl 5,6-dihydro-5-methyl-6-oxo-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H15N3O3
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| Canonical SMILES |
CCOC(=O)C1=C2CN(C(=O)C3=CC=CC=C3N2C=N1)C
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| InChI |
1S/C15H15N3O3/c1-3-21-15(20)13-12-8-17(2)14(19)10-6-4-5-7-11(10)18(12)9-16-13/h4-7,9H,3,8H2,1-2H3
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| InChIKey |
HNGRWUCKESPKRC-UHFFFAOYSA-N
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| CAS Number |
CAS 78756-03-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| Serotonergic synapse | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. | |||
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