Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0TO2R
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| Drug Name |
Fludarabine phosphate
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| Synonyms |
Gedeptin; fludarabine phosphate; 75607-67-9; fludara; Fludarabine 5'-monophosphate; Fludura; Oforta; 2-Fluoro-ARA AMP; Fludarabine (phosphate); Fludarabine monophosphate; FAMP; UNII-1X9VK9O1SC; NSC-312887; C10H13FN5O7P; 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine; 2-Fluoroadenine arabinoside 5'-monophosphate; NSC 312887; NSC 328002; 1X9VK9O1SC; 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate; Fludarabine Phosphate (Fludara); 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate; CHEBI:63599; 9-beta-D-Arab
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
| Company |
PNP Therapeutics Birmingham, LA
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| Structure |
 |
Download2D MOL |
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| Formula |
C10H13FN5O7P
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| Canonical SMILES |
C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N
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| InChI |
1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1
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| InChIKey |
GIUYCYHIANZCFB-FJFJXFQQSA-N
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| CAS Number |
CAS 75607-67-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:63599
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| ADReCS Drug ID | BADD_D00915 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacillales | ||||
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Studied Microbe: Listeria welshimeri serovar 6b str. SLCC5334
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[2] | |||
| Hierarchy | ||||
| Metabolic Effect | Increase activity | |||
| Description | Fludarabine de phosphate can be metabolized by Listeria welshimeri serovar 6b str. SLCC5334, which results in the increase of the drug's activity. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia coli Nissle 1917
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[2] | |||
| Hierarchy | ||||
| Metabolic Effect | Increase activity | |||
| Description | Fludarabine de phosphate can be metabolized by Escherichia coli Nissle 1917, which results in the increase of the drug's activity. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Local bacteria affect the efficacy of chemotherapeutic drugs. Sci Rep. 2015 Sep 29;5:14554. | |||
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