Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U0AY
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| Former ID |
DIB009221
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| Drug Name |
AV-101
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| Synonyms |
Anti-epileptic, VistaGen; L-4-chlorokynurenine; NMDA receptor antagonists, University of Maryland/VistaGen; 4-Cl-kynurenine, NIH/VistaGen; 7-Chlorokynurenic acid; 7-Cl-KYN; 7-Cl-KYNA, NIH
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| Indication | Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2] | Phase 2 | [1] | |
| Neuropathic pain [ICD-11: 8E43.0] | Phase 2 | [2] | ||
| Company |
Vistagen therapeutics
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| Structure |
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Download2D MOL |
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| Formula |
C10H11ClN2O3
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| Canonical SMILES |
C1=CC(=C(C=C1Cl)N)C(=O)CC(C(=O)O)N
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| InChI |
1S/C10H11ClN2O3/c11-5-1-2-6(7(12)3-5)9(14)4-8(13)10(15)16/h1-3,8H,4,12-13H2,(H,15,16)/t8-/m0/s1
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| InChIKey |
HQLHZNDJQSRKDT-QMMMGPOBSA-N
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| CAS Number |
CAS 153152-32-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | N-methyl-D-aspartate receptor (NMDAR) | Target Info | Antagonist | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | ClinicalTrials.gov (NCT02484456) Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder. | |||
| REF 3 | Clinical pipeline report, company report or official report of VistaGen Therapeutics, Inc. | |||
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