Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U0KW
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| Former ID |
DAP000070
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| Drug Name |
Ramelteon
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| Synonyms |
Rozerem; Ramelteon [USAN]; Rozerem (TN); TAK-375; Ramelteon (JAN/USAN/INN); Rozerem, TAK-375, Ramelteon; N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide; N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]fur-8-yl]ethyl}propanamid; (-)-N-(2-(((8S)-1,6,7,8-Tetrahydro-2H-indeno(5,4-b)furan-8-yl)ethyl)propanamide; (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno-(5,4)furan-8-yl)ethyl)propionamide
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| Drug Type |
Small molecular drug
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| Indication | Insomnia [ICD-11: 7A00-7A0Z] | Approved | [1], [2] | |
| Circadian rhythm sleep disorder [ICD-11: 7A60-7A65; ICD-10: G47.2; ICD-9: 327.3, 780.55] | Terminated | [1], [2] | ||
| Therapeutic Class |
Hypnotics and Sedatives
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| Company |
Takeda
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| Structure |
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Download2D MOL |
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| Formula |
C16H21NO2
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| Canonical SMILES |
CCC(=O)NCCC1CCC2=C1C3=C(C=C2)OCC3
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| InChI |
1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1
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| InChIKey |
YLXDSYKOBKBWJQ-LBPRGKRZSA-N
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| CAS Number |
CAS 196597-26-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9368722, 12015157, 14823708, 14847999, 17396858, 26612945, 30413545, 46505923, 47810466, 50070191, 50070903, 50810551, 57399556, 71825382, 81065549, 85789647, 90342558, 92124722, 92307942, 92721412, 99437057, 103370203, 103838767, 104011788, 113442055, 117539034, 124757124, 124772078, 125163928, 126592922, 126627642, 126651547, 126667057, 129814520, 134337398, 135184679, 135651228, 136949090, 137005126, 142796849, 143496454, 152035160, 152164855, 152237728, 152258949, 160647794, 160964318, 162011666, 162184404, 163122411
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| ChEBI ID |
CHEBI:109549
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| ADReCS Drug ID | BADD_D01908 | |||
| SuperDrug ATC ID |
N05CH02
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.604; p = 0.003). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.481; p = 0.033). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.652; p = 0.039). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.587; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.507; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.72; p = 0.001). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.394; p = 0.041). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.367; p = 0.038). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.472; p = 0.038). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.769; p = 0.003). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.57; p = 0.004). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.573; p = 0.018). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Odoribacter splanchnicus (log2FC = -0.51; p = 0.025). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.577; p = 0.008). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.383; p = 0.025). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.394; p = 0.012). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Bifidobacterium ruminantium (log2FC = -0.34; p = 0.049). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ramelteon can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.466; p = 0.003). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melatonin receptor type 1A (MTNR1A) | Target Info | Modulator | [4], [5] |
| Melatonin receptor type 1B (MTNR1B) | Target Info | Modulator | [4], [5] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Circadian entrainment | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1356). | |||
| REF 2 | Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. J Med Chem. 2014 Apr 24;57(8):3161-85. | |||
| REF 5 | Ramelteon: a melatonin receptor agonist for the treatment of insomnia. J Postgrad Med. 2008 Jan-Mar;54(1):45-8. | |||
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