Drug Information
Drug General Information | Top | |||
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Drug ID |
D0U0MZ
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Drug Name |
Lactam derivative 2
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Synonyms |
PMID25470667-Compound-Figure5-15
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Drug Type |
Small molecular drug
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Company |
GLAXOSMITHKLINE LLGLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED QIN, Donghui CHEUNG, Mui JOSHI, Hemant TANGIRALA, Raghuram BETHI, Sridhar, Reddy
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Structure |
Download2D MOL |
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Formula |
C20H15ClN6O2
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Canonical SMILES |
C1COC2=NC=NC(=C2C(=O)N1C3=CN=C4C(=C3)C=CN4C5=CC(=CC=C5)Cl)N
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InChI |
1S/C20H15ClN6O2/c21-13-2-1-3-14(9-13)26-5-4-12-8-15(10-23-18(12)26)27-6-7-29-19-16(20(27)28)17(22)24-11-25-19/h1-5,8-11H,6-7H2,(H2,22,24,25)
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InChIKey |
IHNUTZUAQGMDQV-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [1] |
Target's Patent Info | Diacylglycerol acyltransferase 1 (DGAT1) | Target's Patent Info | [1] | |
BioCyc | Triacylglycerol biosynthesis | |||
KEGG Pathway | Glycerolipid metabolism | |||
Retinol metabolism | ||||
Metabolic pathways | ||||
Fat digestion and absorption | ||||
Pathwhiz Pathway | Retinol Metabolism | |||
Reactome | Acyl chain remodeling of DAG and TAG | |||
Triglyceride Biosynthesis | ||||
WikiPathways | Vitamin A and Carotenoid Metabolism | |||
Statin Pathway | ||||
Triacylglyceride Synthesis | ||||
Glycerophospholipid biosynthesis | ||||
Fatty acid, triacylglycerol, and ketone body metabolism |
References | Top | |||
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REF 1 | Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. |
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