Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U3DU
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| Former ID |
DAP000233
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| Drug Name |
Dexmedetomidine
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| Synonyms |
Dexmedetomidina; Dexmedetomidinum; MPV 1440; MPV-1440; Precedex (TN); Dexmedetomidine (USAN/INN); (+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole; 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole; 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
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| Drug Type |
Small molecular drug
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| Indication | Irritability [ICD-11: MB24; ICD-10: R52, G89; ICD-9: 338] | Approved | [1], [2] | |
| Therapeutic Class |
Hypnotics and Sedatives
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| Company |
Hospira
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| Structure |
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Download2D MOL |
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| Formula |
C13H16N2
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| Canonical SMILES |
CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C
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| InChI |
1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
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| InChIKey |
CUHVIMMYOGQXCV-NSHDSACASA-N
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| CAS Number |
CAS 113775-47-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9653, 7847580, 7979053, 11056249, 11114268, 14773099, 39340796, 46507406, 49658623, 50373284, 53788054, 57359345, 103205132, 103985093, 114155193, 127679087, 134337547, 135650174, 137128737, 137248545, 142472730, 162009785, 163122354, 164780349, 175267064, 175270067, 179149622, 184526375, 204376627, 224663060, 226087975, 226414290, 251916847, 251918086, 252347941, 252429689, 252471419, 252672010
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| ChEBI ID |
CHEBI:4466
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| ADReCS Drug ID | BADD_D00629 ; BADD_D00630 | |||
| SuperDrug ATC ID |
N05CM18
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor Alpha-2 (ADRA2) | Target Info | Agonist | [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 521). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Dexmedetomidine in intensive care unit: a study of hemodynamic changes. Middle East J Anesthesiol. 2002 Oct;16(6):587-95. | |||
| REF 4 | Alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia. 1999 Feb;54(2):146-65. | |||
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