Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U3ED
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| Former ID |
DCL000788
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| Drug Name |
E-2007
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| Synonyms |
Perampanel; E 2007; Perampanel (USAN); 2-(2-oxo-1-phenyl-5-pyridin-2-yl-pyridin-3-yl)benzonitrile; 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
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| Drug Type |
Small molecular drug
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| Indication | Diabetic neuropathy [ICD-11: 8C0Z; ICD-10: G63, G63.2] | Approved | [1], [2] | |
| Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Discontinued in Phase 3 | [1], [3] | ||
| Company |
Eisai Co. Ltd.
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H15N3O
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| Canonical SMILES |
C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
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| InChI |
1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
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| InChIKey |
PRMWGUBFXWROHD-UHFFFAOYSA-N
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| CAS Number |
CAS 380917-97-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14896254, 24201162, 46046112, 78829933, 96025647, 104179157, 104240302, 135253308, 136349971, 137069512, 140744775, 160646231, 162168968, 162223172, 162509113, 163620812, 163686138, 175268698, 178103629, 186014849, 187071926, 218903093, 223701414, 223850914, 226087529, 226553205, 244259846, 249858958, 250224845, 252069089, 252216026, 252437024, 252451824, 252480440
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| ChEBI ID |
CHEBI:71013
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| ADReCS Drug ID | BADD_D01733 | |||
| SuperDrug ATC ID |
N03AX22
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7050). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. | |||
| REF 4 | Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. | |||
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