Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U5VZ
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| Former ID |
DAP001061
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| Drug Name |
Bepotastine
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| Synonyms |
Betotastine; Tau 284; TAU-284DS; Talion (TN); (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid; 4-((4-Chlorophenyl)-2-pyridinylmethoxy)-1-piperidinebutanoic acid; 4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
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| Drug Type |
Small molecular drug
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| Indication | Allergic rhinitis [ICD-11: CA08.0] | Approved | [1], [2] | |
| Therapeutic Class |
Antiallergic Agents
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| Company |
Tanabe Seiyaku Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H25ClN2O3
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| Canonical SMILES |
C1CN(CCC1OC(C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O
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| InChI |
1S/C21H25ClN2O3/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26)/t21-/m0/s1
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| InChIKey |
YWGDOWXRIALTES-NRFANRHFSA-N
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| CAS Number |
CAS 125602-71-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14829848, 14902947, 23920714, 46238701, 75020756, 103813930, 113454187, 117462449, 119526563, 123087811, 124490445, 127327794, 127327795, 129857231, 135086471, 135374324, 137005445, 142507415, 143495901, 152053402, 152237662, 160646105, 162189322, 163300204, 164829665, 174528119, 175266558, 175438136, 176251674, 179150117, 187051769, 210276615, 210279871, 211534992, 223532849, 223756030, 226416530, 249855756, 250194992, 251916770, 251918009, 252077531, 252430565, 252434265
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| ChEBI ID |
CHEBI:71204
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| ADReCS Drug ID | BADD_D00252 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7466). | |||
| REF 2 | Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20. | |||
| REF 3 | Mast cells play a critical role in the pathogenesis of viral myocarditis. Circulation. 2008 Jul 22;118(4):363-72. | |||
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