Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U7PS
|
|||
| Former ID |
DCL000375
|
|||
| Drug Name |
GSK256066
|
|||
| Synonyms |
GSK-256066
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8] | Discontinued in Phase 2 | [1] | |
| Company |
GSK
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C27H26N4O5S
|
|||
| Canonical SMILES |
CC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C
|
|||
| InChI |
1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30)
|
|||
| InChIKey |
JFHROPTYMMSOLG-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 13122-87-7
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
14787174, 24129924, 44926098, 75157187, 103704123, 124360777, 125164690, 125653374, 131326858, 134339024, 136340322, 136349521, 136367652, 136920333, 137685009, 144116030, 152258227, 160647063, 162011384, 162038031, 162202759, 163364025, 163642651, 163913562, 164194085, 170482606, 174006286, 174530826, 180191800, 185998827, 198983498, 223682017, 223705159, 227387094, 242059766, 242591500, 247189701, 251963086, 251971295, 252110118, 252215508, 252449266, 252451559
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Purine metabolism | |||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | DARPP-32 events | |||
| G alpha (s) signalling events | ||||
| WikiPathways | G Protein Signaling Pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024245) | |||
| REF 2 | Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.