Drug Information
Drug General Information | Top | |||
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Drug ID |
D0U9JL
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Former ID |
DIB016997
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Drug Name |
LY-223982
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Synonyms |
CGS-23131; LY-223980; LY-255253; SKF-107324
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Drug Type |
Small molecular drug
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Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Discontinued in Phase 2 | [1], [2] | |
Company |
Eli Lilly & Co
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Structure |
Download2D MOL |
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Formula |
C30H30O7
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Canonical SMILES |
COC1=CC=C(C=C1)C=CCCCCOC2=C(C=C(C=C2)C(=O)C3=CC(=CC=C3)C(=O)O)CCC(=O)O
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InChI |
1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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InChIKey |
SYZSSLLFRVDRHL-QPJJXVBHSA-N
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CAS Number |
CAS 117423-74-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Leukotriene B4 receptor 1 (LTB4R) | Target Info | Modulator | [3] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
NetPath Pathway | IL4 Signaling Pathway | |||
Reactome | Leukotriene receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | Nucleotide GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Spinal Cord Injury | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3415). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002326) | |||
REF 3 | Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther. 1992 Dec;263(3):1009-14. |
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