Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0UA9J
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| Former ID |
DIB007637
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| Drug Name |
VT-1129
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| Synonyms |
Metalloenzyme inhibitors (fungal infection); VT-1161; VT-1235; Metalloenzyme inhibitors (fungal infection), Viamet
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| Indication | Onchocerciasis [ICD-11: 1F6A; ICD-10: B73] | Phase 2 | [1] | |
| Onychomycosis [ICD-11: EE12.1] | Phase 2 | [2] | ||
| Cryptococcal meningitis infection [ICD-11: 1D01.10] | Phase 1 | [3] | ||
| Company |
Viamet pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C22H14F7N5O2
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| Canonical SMILES |
C1=CC(=CC=C1C2=CN=C(C=C2)C(C(CN3C=NN=N3)(C4=C(C=C(C=C4)F)F)O)(F)F)OC(F)(F)F
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| InChI |
1S/C22H14F7N5O2/c23-15-4-7-17(18(24)9-15)20(35,11-34-12-31-32-33-34)21(25,26)19-8-3-14(10-30-19)13-1-5-16(6-2-13)36-22(27,28)29/h1-10,12,35H,11H2/t20-/m0/s1
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| InChIKey |
NCEHACHJIXJSPD-FQEVSTJZSA-N
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| CAS Number |
CAS 1340593-70-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Enzyme unspecific (Enz) | Target Info | Inhibitor | [4] |
| Lanosterol 14-alpha demethylase (CYP51A1) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Steroid biosynthesis | |||
| Metabolic pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01891305) A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Moderate - Severe Interdigital Tinea Pedis. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 4 | The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. | |||
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