Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0UR9D
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| Former ID |
DNC014308
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| Drug Name |
3-benzyl-2-mercapto-6-nitroquinazolin-4(3H)-one
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| Synonyms |
CHEMBL1093884; 3-benzyl-2-mercapto-6-nitroquinazolin-4(3H)-one; BDBM50316110
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H11N3O3S
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| Canonical SMILES |
C1=CC=C(C=C1)CN2C(=O)C3=C(C=CC(=C3)[N+](=O)[O-])NC2=S
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| InChI |
1S/C15H11N3O3S/c19-14-12-8-11(18(20)21)6-7-13(12)16-15(22)17(14)9-10-4-2-1-3-5-10/h1-8H,9H2,(H,16,22)
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| InChIKey |
CAFCJNRLHXPRGN-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg Med Chem. 2010 Apr 15;18(8):2849-63. | |||
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