Drug Information
Drug General Information | Top | |||
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Drug ID |
D0V0AW
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Former ID |
DIB021025
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Drug Name |
TC-2559
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Synonyms |
TC2559
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C12H18N2O
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Canonical SMILES |
CCOC1=CN=CC(=C1)C=CCCNC
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InChI |
1S/C12H18N2O/c1-3-15-12-8-11(9-14-10-12)6-4-5-7-13-2/h4,6,8-10,13H,3,5,7H2,1-2H3/b6-4+
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InChIKey |
HFZDMKMXPGRKCK-GQCTYLIASA-N
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:93177
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Target and Pathway | Top | |||
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Target(s) | Neuronal acetylcholine receptor beta-2 (CHRNB2) | Target Info | Agonist | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Cholinergic synapse | ||||
Nicotine addiction | ||||
Panther Pathway | Nicotinic acetylcholine receptor signaling pathway | |||
Nicotine pharmacodynamics pathway | ||||
Reactome | Highly sodium permeable acetylcholine nicotinic receptors | |||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Highly calcium permeable nicotinic acetylcholine receptors | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Nicotine Activity on Dopaminergic Neurons |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3987). | |||
REF 2 | The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology. 2003 Sep;45(3):334-44. |
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