Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V1UL
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| Former ID |
DNC012802
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| Drug Name |
6-(2-Phenylsulfanyl-ethyl)-pteridine-2,4-diamine
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| Synonyms |
CHEMBL50379; 6-(2-phenylsulfanylethyl)pteridine-2,4-diamine; AC1L9YC2; 6-(2-Phenylsulfanyl-ethyl)-pteridine-2,4-diamine; BDBM50127151; 2,4-Pteridinediamine, 6-[2-(phenylthio)ethyl]-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H14N6S
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| Canonical SMILES |
C1=CC=C(C=C1)SCCC2=CN=C3C(=N2)C(=NC(=N3)N)N
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| InChI |
1S/C14H14N6S/c15-12-11-13(20-14(16)19-12)17-8-9(18-11)6-7-21-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H4,15,16,17,19,20)
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| InChIKey |
OVPXUMDQGFGLQK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three ... J Med Chem. 2003 Apr 24;46(9):1726-36. | |||
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