Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V3ZX
|
|||
| Former ID |
DIB000596
|
|||
| Drug Name |
DA-3607
|
|||
| Synonyms |
Ad-stTRAIL; TRAIL adenoviral gene therapy (cancer), Dong-A
Click to Show/Hide
|
|||
| Indication | Brain cancer [ICD-11: 2A00] | Phase 1 | [1] | |
| Company |
Dong-A Pharmaceutical Co Ltd
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | TNF related apoptosis inducing ligand (TNFSF10) | Target Info | Binder | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| FoxO signaling pathway | ||||
| Apoptosis | ||||
| Natural killer cell mediated cytotoxicity | ||||
| Measles | ||||
| Influenza A | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| TNFalpha Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| Panther Pathway | Apoptosis signaling pathway | |||
| Pathway Interaction Database | TRAIL signaling pathway | |||
| Caspase Cascade in Apoptosis | ||||
| Reactome | Ligand-dependent caspase activation | |||
| Regulation by c-FLIP | ||||
| RIPK1-mediated regulated necrosis | ||||
| CASP8 activity is inhibited | ||||
| Dimerization of procaspase-8 | ||||
| TRAIL signaling | ||||
| WikiPathways | Apoptosis | |||
| Extrinsic Pathway for Apoptosis | ||||
| Apoptosis Modulation and Signaling | ||||
| TP53 Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026657) | |||
| REF 2 | Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Ther. 2006 Feb;13(4):330-8. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.