Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V4GI
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| Former ID |
DNC011501
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| Drug Name |
CGS-9896
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| Synonyms |
Cgs-9896; Cgs 9896; 77779-36-3; UNII-86PWQ4PVN0; 86PWQ4PVN0; AC1Q3J9C; AC1L337H; SCHEMBL7308514; AC1Q3T13; 2-(4-chlorophenyl)-1H-pyrazolo[4,3-c]quinolin-3-one; SCHEMBL17236324; CTK5E4889; BDBM84957; AOB4759; MolPort-009-714-150; CQINXWYVIOMBEI-UHFFFAOYSA-N; PDSP2_001748; 2-(4-chlorophenyl)-1,2-dihydro-3h-pyrazolo[4,3-c]quinolin-3-one; PDSP1_001765; ZINC100367629; AKOS021973584; MCULE-9708849911; A10022; 2-(p-chlorophenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one; F3406-4901; 2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H10ClN3O
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| Canonical SMILES |
C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
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| InChI |
1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H
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| InChIKey |
QCBUAKLOWCOUCR-UHFFFAOYSA-N
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| CAS Number |
CAS 77779-36-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. | |||
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