Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V7GC
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| Former ID |
DIB008730
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| Drug Name |
Rolafagrel
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| Synonyms |
FCE-22178
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| Drug Type |
Small molecular drug
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| Indication | Nephritis [ICD-11: GB40] | Discontinued in Phase 2 | [1] | |
| Company |
Pharmacia & Upjohn AB
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H12N2O2
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| Canonical SMILES |
C1CC(=CC2=C1C=CC(=C2)C(=O)O)N3C=CN=C3
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| InChI |
1S/C14H12N2O2/c17-14(18)11-2-1-10-3-4-13(8-12(10)7-11)16-6-5-15-9-16/h1-2,5-9H,3-4H2,(H,17,18)
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| InChIKey |
DQEDSIVMYUUZCK-UHFFFAOYSA-N
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| CAS Number |
CAS 89781-55-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thromboxane-A synthase (TBXAS1) | Target Info | Inhibitor | [2] |
| BioCyc | C20 prostanoid biosynthesis | |||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| Platelet activation | ||||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| Arachidonic acid metabolism | ||||
| Phase 1 - Functionalization of compounds | ||||
| Eicosanoid Synthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001438) | |||
| REF 2 | Inhibition by FCE 22178 of platelet and glomerular thromboxane synthase in animal and human kidney disease. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:707-10. | |||
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