Drug Information
Drug General Information | Top | |||
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Drug ID |
D0V7QU
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Drug Name |
Ureido-phenyl-substituted triazine derivative 2
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Synonyms |
PMID28270010-Compound-Figure6-2
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Drug Type |
Small molecular drug
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Company |
ABRAXIS BIOSCIENCE, LLC
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Structure |
Download2D MOL |
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Formula |
C25H27N9OS2
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Canonical SMILES |
CC1=CN=C(S1)NC2=NC(=NC(=N2)SC3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4)N5CCN(CC5)C
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InChI |
1S/C25H27N9OS2/c1-17-16-26-24(36-17)30-21-29-22(34-14-12-33(2)13-15-34)32-25(31-21)37-20-10-8-19(9-11-20)28-23(35)27-18-6-4-3-5-7-18/h3-11,16H,12-15H2,1-2H3,(H2,27,28,35)(H,26,29,30,31,32)
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InChIKey |
RZAWEAWFWJQMTD-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Tropomyosin-related kinase A (TrkA) | Target Info | Inhibitor | [1] |
Target's Patent Info | Tropomyosin-related kinase A (TrkA) | Target's Patent Info | [1] | |
KEGG Pathway | MAPK signaling pathway | |||
Endocytosis | ||||
Apoptosis | ||||
Neurotrophin signaling pathway | ||||
Inflammatory mediator regulation of TRP channels | ||||
Pathways in cancer | ||||
Transcriptional misregulation in cancer | ||||
Thyroid cancer | ||||
Central carbon metabolism in cancer | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
Pathway Interaction Database | Neurotrophic factor-mediated Trk receptor signaling | |||
Reactome | Frs2-mediated activation | |||
ARMS-mediated activation | ||||
NGF-independant TRKA activation | ||||
PI3K/AKT activation | ||||
WikiPathways | MAPK Signaling Pathway | |||
BDNF signaling pathway | ||||
Integrated Pancreatic Cancer Pathway | ||||
NGF signalling via TRKA from the plasma membrane |
References | Top | |||
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REF 1 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. |
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