Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V8QT
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| Former ID |
DAP000787
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| Drug Name |
Chlorambucil
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| Synonyms |
Ambochlorin; Amboclorin; Chlocambucil; Chloorambucol; Chlorambucilum; Chloraminophen; Chloraminophene; Chlorbutin; Chlorbutine; Chlorbutinum; Chloroambucil; Chlorobutin; Chlorobutine; Clorambucile; Clorambucilo; Ecloril; Elcoril; Elcorin; Leukeran; Leukersan; Leukoran; Linfolizin; Linfolysin; Lympholysin; Clorambucile [DCIT]; Glaxo Wellcome Brand of Chlorambucil; GlaxoSmithKline Brand of Chlorambucil; Leuk ersan; Leukeran tablets; Phenylbutyric acid nitrogen mustard; Wellcome Brand of Chlorambucil; C0253; CB 1348; CB1348; Cb l348; CB-1348; Chlorambucil [INN:BAN]; Chlorambucilum [INN-Latin]; Clorambucilo [INN-Spanish]; LEUKERAN (TN); Leukeran (TN); Phenylbuttersaeure-lost; Phenylbuttersaeure-lost[German]; Chlorambucil (USP/INN)
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| Drug Type |
Small molecular drug
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| Indication | Chronic lymphocytic leukaemia [ICD-11: 2A82.0; ICD-10: C83.0, C91.1] | Approved | [1], [2] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
GlaxoSmithKline
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H19Cl2NO2
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| Canonical SMILES |
C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
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| InChI |
1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
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| InChIKey |
JCKYGMPEJWAADB-UHFFFAOYSA-N
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| CAS Number |
CAS 305-03-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9117, 69624, 611297, 855863, 3184022, 4963890, 7847332, 7886485, 7978915, 8149242, 8151754, 10517880, 11110896, 11110897, 11335863, 11361102, 11362972, 11365534, 11368096, 11371291, 11373905, 11376258, 11407032, 11462074, 11467107, 11468227, 11483985, 11486735, 11487881, 11490152, 11492088, 11493932, 11533216, 14825408, 17389986, 17404790, 24278287, 24853850, 26611647, 26680120, 26747014, 26747015, 26747016, 26747017, 29215014, 29221865, 46506842, 47216784, 47291145, 47515327
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| ChEBI ID |
CHEBI:28830
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| ADReCS Drug ID | BADD_D00429 | |||
| SuperDrug ATC ID |
L01AA02
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| SuperDrug CAS ID |
cas=000305033
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA replication (DNA repli) | Target Info | Intercalator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7143). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010669. | |||
| REF 3 | Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A. Mol Cancer Ther. 2009 Jun;8(6):1714-23. | |||
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