Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V8VY
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| Former ID |
DNC004761
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| Drug Name |
2-Pyrrolidin-1-yl-benzo[h]chromen-4-one
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| Synonyms |
K 12344; BRN 0412624; 4H-Naphtho(1,2-b)pyran-4-one, 2-(1-pyrrolidinyl)-; CHEMBL179914; 2-(1-Pyrrolidinyl)-4H-naphtho(1,2-b)pyran-4-one; 2-(N-Pirrolidil)-4-oxo-4H-nafto(1,2-b)pirano [Italian]; 61035-04-9; 2-Pyrrolidin-1-yl-benzo[h]chromen-4-one; AC1MIJ0D; 2-(N-Pirrolidil)-4-oxo-4H-nafto(1,2-b)pirano; SCHEMBL3535232; DTXSID00209910; BDBM50159631; 2-pyrrolidin-1-ylbenzo[h]chromen-4-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H15NO2
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| Canonical SMILES |
C1CCN(C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
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| InChI |
1S/C17H15NO2/c19-15-11-16(18-9-3-4-10-18)20-17-13-6-2-1-5-12(13)7-8-14(15)17/h1-2,5-8,11H,3-4,9-10H2
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| InChIKey |
CYNBNMZZLAYOIM-UHFFFAOYSA-N
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| CAS Number |
CAS 61035-04-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Non-homologous end-joining | |||
| Cell cycle | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
| Coregulation of Androgen receptor activity | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| BARD1 signaling events | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | |||
| WikiPathways | DNA Damage Response | |||
| Non-homologous end joining | ||||
| FAS pathway and Stress induction of HSP regulation | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Retinoblastoma (RB) in Cancer | ||||
| Prostate Cancer | ||||
| Double-Strand Break Repair | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. | |||
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