Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V9OL
|
|||
| Former ID |
DIB000631
|
|||
| Drug Name |
534U87
|
|||
| Synonyms |
Anticonvulsant, Glaxo Wellcome; BW-534U87
Click to Show/Hide
|
|||
| Indication | Epileptic seizures [ICD-11: 8A61-8A6Z; ICD-9: 345.9, 780.3] | Discontinued in Phase 2 | [1] | |
| Company |
Burroughs Wellcome Inc
|
|||
| Structure |
 |
Download2D MOL
|
||
| Formula |
C12H10ClF2N5
|
|||
| Canonical SMILES |
C1=CC(=C(C(=C1)F)CN2C3=C(C(=NC=C3)N)N=N2)F.Cl
|
|||
| InChI |
1S/C12H9F2N5.ClH/c13-8-2-1-3-9(14)7(8)6-19-10-4-5-16-12(15)11(10)17-18-19;/h1-5H,6H2,(H2,15,16);1H
|
|||
| InChIKey |
JKXUBXRPDZPXOD-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 143153-93-9
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium channel unspecific (NaC) | Target Info | Modulator | [2] |
| KEGG Pathway | Dopaminergic synapse | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006296) | |||
| REF 2 | The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels. Br J Pharmacol. 1999 Nov;128(5):1011-20. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.