Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V9XF
|
|||
| Former ID |
DNC014803
|
|||
| Drug Name |
PICROTIN
|
|||
| Synonyms |
picrotin; 21416-53-5; DSSTox_CID_25605; DSSTox_RID_80998; UNII-U06Z6QD7N2; DSSTox_GSID_45605; CHEMBL478523; U06Z6QD7N2; CHEBI:8205; CAS-124-87-8; ST057242; (5S,8S,12S,14S,1R,3R,9R,13R)-1-hydroxy-14-(1-hydroxy-isopropyl)-13-methyl-4,7, 10-trioxapentacyclo[6.4.1.1< Pikrotin; Picrotin (from Anamirta cocculus seed); NSC 129536; BRN 5302552; NCGC00017246-02; 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C15H18O7
|
|||
| Canonical SMILES |
CC12C3C4C(C(C1(CC5C2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O
|
|||
| InChI |
1S/C15H18O7/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9/h5-9,18-19H,4H2,1-3H3/t5-,6+,7-,8-,9-,13-,14-,15+/m1/s1
|
|||
| InChIKey |
RYEFFICCPKWYML-QCGISDTRSA-N
|
|||
| CAS Number |
CAS 21416-53-5
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
11719, 8149144, 10298999, 11335931, 11361170, 11363307, 11365869, 11368431, 11371205, 11375459, 11376593, 11462142, 11483894, 11488095, 11489889, 11493595, 11494227, 11537361, 12174785, 14800915, 26611500, 26680147, 29204484, 36885859, 47440284, 47440285, 48259258, 48259259, 48484021, 50109819, 50956284, 57403989, 87352014, 92124834, 99301844, 103639231, 104115363, 104627248, 124558826, 124637665, 134352008, 135118322, 137241488, 141839280, 144204357, 144204813, 178101103, 179039605, 198977117, 198983475
|
|||
| ChEBI ID |
CHEBI:8205
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycine receptor (GlyR) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | Iron uptake and transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4286). | |||
| REF 2 | Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors. J Biol Chem. 2007 Jun 1;282(22):16016-35. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.