Drug Information
Drug General Information | Top | |||
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Drug ID |
D0VH8A
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Former ID |
DNC006865
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Drug Name |
N-(4-(3-(pyridin-2-yl)acryloyl)phenyl)acetamide
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Synonyms |
AC1O17NE; CHEMBL425789
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C16H14N2O2
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Canonical SMILES |
CC(=O)NC1=CC=C(C=C1)C(=O)C=CC2=CC=CC=N2
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InChI |
1S/C16H14N2O2/c1-12(19)18-15-7-5-13(6-8-15)16(20)10-9-14-4-2-3-11-17-14/h2-11H,1H3,(H,18,19)/b10-9+
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InChIKey |
LAXKVXCZXLEVKG-MDZDMXLPSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Tubulin beta (TUBB) | Target Info | Inhibitor | [1] |
Tubulin beta-2 chain (TUBB2) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Phagosome | |||
Gap junction | ||||
Pathogenic Escherichia coli infection | ||||
NetPath Pathway | FSH Signaling Pathway | |||
TCR Signaling Pathway | ||||
EGFR1 Signaling Pathway | ||||
Panther Pathway | Cytoskeletal regulation by Rho GTPase | |||
Huntington disease | ||||
Reactome | Regulation of PLK1 Activity at G2/M Transition | |||
Loss of Nlp from mitotic centrosomes | ||||
Recruitment of mitotic centrosome proteins and complexes | ||||
Loss of proteins required for interphase microtubule organization?from the centrosome | ||||
Anchoring of the basal body to the plasma membrane | ||||
WikiPathways | Parkin-Ubiquitin Proteasomal System pathway | |||
Pathogenic Escherichia coli infection | ||||
Mitotic G2-G2/M phases |
References | Top | |||
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REF 1 | Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin. J Med Chem. 2006 Sep 21;49(19):5664-70. |
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