Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W4ZU
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| Former ID |
DNC012053
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| Drug Name |
KURARINOL
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| Synonyms |
Kurarinol; CHEBI:81093; 855746-98-4; CHEMBL455667; MolPort-039-338-650; ZINC13817026; BDBM50366788; C17444
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C26H32O7
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| Canonical SMILES |
CC(=C)C(CCC(C)(C)O)CC1=C2C(=C(C=C1O)OC)C(=O)CC(O2)C3=C(C=C(C=C3)O)O
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| InChI |
1S/C26H32O7/c1-14(2)15(8-9-26(3,4)31)10-18-20(29)12-23(32-5)24-21(30)13-22(33-25(18)24)17-7-6-16(27)11-19(17)28/h6-7,11-12,15,22,27-29,31H,1,8-10,13H2,2-5H3/t15-,22+/m1/s1
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| InChIKey |
XMUPAAIHKAIUSU-QRQCRPRQSA-N
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| CAS Number |
CAS 855746-98-4
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:81093
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 3A (PDE3A) | Target Info | Inhibitor | [1] |
| Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [1] | |
| Phosphodiesterase 4B (PDE4B) | Target Info | Inhibitor | [1] | |
| Phosphodiesterase 5A (PDE5A) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Purine metabolism | |||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| cGMP-PKG signaling pathway | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Reactome | DARPP-32 events | |||
| G alpha (s) signalling events | ||||
| cGMP effects | ||||
| WikiPathways | G Protein Signaling Pathways | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| Myometrial Relaxation and Contraction Pathways | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Opioid Signalling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. | |||
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