Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W5IP
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| Former ID |
DNC012996
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| Drug Name |
GNF-PF-3645
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| Synonyms |
GNF-PF-3645; ethyl 6-isopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylate; ethyl 4-hydroxy-6-isopropyl-3-quinolinecarboxylate; AC1LEPYU; Oprea1_718373; CHEMBL202969; SCHEMBL11065820; MolPort-002-693-403; ZINC9761170; STK040682; AKOS005383459; MCULE-2719488867; ST085537; 64321-61-5; EU-0017663; CS-0061597; ethyl 4-hydroxy-6-isopropylquinoline-3-carboxylate; SR-01000511952; AG-670/08515048; SR-01000511952-1; ethyl 4-hydroxy-6-(propan-2-yl)quinoline-3-carboxylate; ethyl 4-oxo-6-propan-2-yl-1H-quinoline-3-carboxylate; ethyl 4-hydroxy-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H17NO3
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| Canonical SMILES |
CCOC(=O)C1=CNC2=C(C1=O)C=C(C=C2)C(C)C
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| InChI |
1S/C15H17NO3/c1-4-19-15(18)12-8-16-13-6-5-10(9(2)3)7-11(13)14(12)17/h5-9H,4H2,1-3H3,(H,16,17)
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| InChIKey |
JBFFEVKDAYLOKF-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. | |||
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