Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W6EP
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| Former ID |
DIB006255
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| Drug Name |
AMG-889436
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| Synonyms |
Metabotropic glutamate receptor 4 agonist (Parkinson's disease), Amgen; Metabotropic glutamate receptor 4 positive allosteric modulator (Parkinson's disease), Amgen
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Investigative | [1] | |
| Company |
Amgen Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate receptor AMPA 4 (GRIA4) | Target Info | Agonist | [1] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Circadian entrainment | ||||
| Retrograde endocannabinoid signaling | ||||
| Glutamatergic synapse | ||||
| Dopaminergic synapse | ||||
| Amphetamine addiction | ||||
| Nicotine addiction | ||||
| Panther Pathway | Ionotropic glutamate receptor pathway | |||
| Metabotropic glutamate receptor group III pathway | ||||
| Reactome | Trafficking of AMPA receptors | |||
| Trafficking of GluR2-containing AMPA receptors | ||||
| Unblocking of NMDA receptor, glutamate binding and activation | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). | |||
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