Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W7UO
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| Former ID |
DCL000083
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| Drug Name |
CGP71683A
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| Synonyms |
CGP-71683A; N-[[4-[[(4-aminoquinazolin-2-yl)amino]methyl]cyclohexyl]methyl]naphthalene-1-sulfonamide
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| Drug Type |
Small molecular drug
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| Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Discontinued in Phase 3 | [1], [2] | |
| Company |
Servier
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| Structure |
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Download2D MOL
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| Formula |
C26H30ClN5O2S
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| Canonical SMILES |
C1CC(CCC1CNC2=NC3=CC=CC=C3C(=N2)N)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54.Cl
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| InChI |
1S/C26H29N5O2S.ClH/c27-25-22-9-3-4-10-23(22)30-26(31-25)28-16-18-12-14-19(15-13-18)17-29-34(32,33)24-11-5-7-20-6-1-2-8-21(20)24;/h1-11,18-19,29H,12-17H2,(H3,27,28,30,31);1H
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| InChIKey |
DIQDKUNCSVFGHH-UHFFFAOYSA-N
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| CAS Number |
CAS 192322-50-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7978910, 11056881, 24739773, 29215520, 29217718, 39341734, 50416313, 57359513, 85209013, 103181545, 103465696, 103987903, 104052019, 114157903, 124892234, 129422299, 129422300, 131333926, 134338780, 134341415, 135650078, 140179814, 142325330, 163715699, 177748548, 179294236, 198970222, 226663935, 242204482, 248078644, 248094099
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuropeptide Y receptor type 5 (NPY5R) | Target Info | Antagonist | [3], [4], [5] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1562). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010609) | |||
| REF 3 | Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors. Neuropharmacology. 2007 May;52(6):1396-402. | |||
| REF 4 | Neuropeptide Y induced modulation of dopamine synthesis in the striatum. Regul Pept. 2005 Jul 15;129(1-3):73-8. | |||
| REF 5 | Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat. Eur J Pharmacol. 2001 Mar 2;414(2-3):215-24. | |||
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