Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W9LJ
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| Former ID |
DNC003294
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| Drug Name |
Metiamide
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| Synonyms |
METIAMIDE; 34839-70-8; Methiamide; Metiamidum; Metiamida; F 92058; 1-Methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)thiourea; Metiamidum [INN-Latin]; Metiamida [INN-Spanish]; SKF 92058; NSC 307755; F-92058; CHEBI:6896; C9H16N4S2; UNII-3K7670861M; FPBPLBWLMYGIQR-UHFFFAOYSA-N; 1-Methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)-2-thiourea; Thiourea, N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-; 3-Methyl-1-(2-((5-methyl-4-imidazolyl)methylthio)ethyl)thiourea; 3K7670861M; Urea, 1-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H16N4S2
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| Canonical SMILES |
CC1=C(N=CN1)CSCCNC(=S)NC
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| InChI |
1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)
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| InChIKey |
FPBPLBWLMYGIQR-UHFFFAOYSA-N
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| CAS Number |
CAS 34839-70-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9652, 454502, 6698911, 8653311, 14774170, 16961280, 17398245, 32248923, 47434826, 47954439, 50061391, 50222525, 57409062, 71922618, 85229947, 89651662, 95515649, 99445275, 103173533, 103914964, 109612907, 110525148, 127879114, 131342042, 134221816, 134998461, 135650597, 137156409, 137263792, 152343567, 160969712, 162011533, 163415887, 163620956, 163686278, 163910534, 166729885, 172868618, 174529016, 179293854, 185990418, 198939253, 223440325, 223563202, 224774955, 226845005, 236556847, 242060280, 249962168, 252215738
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| ChEBI ID |
CHEBI:6896
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H2 receptor (H2R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gastric acid secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Histamine H2 receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | |||
| Gastric Acid Production | ||||
| Reactome | Histamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Secretion of Hydrochloric Acid in Parietal Cells | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1233). | |||
| REF 2 | Metiamide--an orally active histamine H2-receptor antagonist. 1973. Agents Actions. 1994 Dec;43(3-4):91-5; discussion 96. | |||
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