Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W9VB
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| Former ID |
DAP001133
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| Drug Name |
Diphenidol
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| Synonyms |
Avomol; Defenidol; Difenidol; Difenidolo; Difenidolum; Nometic; Vontrol; Difenidol HCl; Difenidolo [DCIT]; SKF 478; Difenidolum [INN-Latin]; Diphenidol [USAN:BAN]; SK-478; Diphenidol (USAN/INN); SK&F-478; Alpha,alpha-Diphenyl-1-piperidinebutanol; Diphenyl(3-(1-piperidyl)propyl)carbinol; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Nausea [ICD-11: MD90; ICD-10: R11] | Approved | [1], [2], [3] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H27NO
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| Canonical SMILES |
C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
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| InChI |
1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2
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| InChIKey |
OGAKLTJNUQRZJU-UHFFFAOYSA-N
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| CAS Number |
CAS 972-02-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9175, 5635332, 8151944, 10538868, 11112531, 11466280, 11467400, 11486019, 15420107, 17397943, 29222201, 46506486, 47291279, 47810922, 47810923, 48334667, 48415910, 49698405, 50015356, 50100475, 56464134, 57321583, 80516491, 85787519, 92251441, 92720233, 103243329, 103816013, 104302396, 106222940, 114916617, 117612528, 118313878, 124882438, 125360426, 126620156, 126667668, 127339718, 127339719, 127339720, 128803775, 134224133, 134338378, 134981108, 137029102, 138363295, 144206624, 160964563, 164826978, 165719084
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| ChEBI ID |
CHEBI:4638
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Muscarinic acetylcholine receptor M4 (CHRM4) | Target Info | Antagonist | [4] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Cholinergic synapse | ||||
| Regulation of actin cytoskeleton | ||||
| Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Reactome | Muscarinic acetylcholine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| Regulation of Actin Cytoskeleton | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7163). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016033. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6. | |||
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