Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0WB9V
|
|||
| Former ID |
DAP001459
|
|||
| Drug Name |
Barbiturate
|
|||
| Synonyms |
Barbituric acid; BARBITURIC ACID; 67-52-7; Malonylurea; 6-Hydroxyuracil; 2,4,6(1H,3H,5H)-Pyrimidinetrione; Pyrimidinetrione; pyrimidine-2,4,6(1H,3H,5H)-trione; 2,4,6-Pyrimidinetrione; Malonylharnstoff; 2,4,6-Trioxohexahydropyrimidine; 1,3-diazinane-2,4,6-trione; Barbitursaeure; Hexahydropyrimidine-2,4,6-trione; Hydrouracil, 6-hydroxy-; Barbituric acid (VAN); Urea, N,N'-(1,3-dioxo-1,3-propanediyl)-; NSC 7889; UNII-WQ92Y2793G; 2,4,6-Pyrimidinetrione(1H,3H,5H); Barbituric acid (VAN) (8CI); CHEBI:16294; EINECS 200-658-0; Barbitursaeure; Pyrimidinetriol; Barbiturate anion; Sodiumbarbiturate; AG-670/31547005; Hexahydro-pyrimidine-2,4,6-trione; Pyrimidine-2,4,6(1H,3H,5H)-trione; 1,2,3,4,5,6-Hexahydro-2,4,6-pyrimidinetrione; 11709_FLUKA; 2,4,6-(1H,3H,5H)-Pyrimidinetrione; 2,4,6-Pyrimidinetriol; 2,4,6-Trihydroxypyrimidine; 2,4,6-trioxotetrahydro-2H-pyrimidin-1-ide; 4,6-dioxo-1H-pyrimidin-2-olate
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Anaesthesia [ICD-11: 9A78.6; ICD-10: R52, G89; ICD-9: 338] | Approved | [1] | |
| Depression [ICD-11: 6A70-6A7Z; ICD-9: 311] | Approved | [2] | ||
| Structure |
 |
Download2D MOL |
||
| Formula |
C4H4N2O3
|
|||
| Canonical SMILES |
C1C(=O)NC(=O)NC1=O
|
|||
| InChI |
1S/C4H4N2O3/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)
|
|||
| InChIKey |
HNYOPLTXPVRDBG-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 67-52-7
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
4071, 73654, 610615, 839197, 3137537, 3727084, 5630165, 8145676, 8153899, 10532462, 15461893, 24847314, 24851157, 29225209, 48413258, 49857195, 57323260, 57955591, 74498975, 85083143, 85165145, 85247090, 92298605, 103695223, 103811900, 104311418, 104837276, 117593533, 118081819, 124955112, 125308349, 125308617, 125355973, 126546422, 126677922, 127279485, 127279486, 127279487, 127341845, 127341846, 127354639, 131269178, 131323285, 134338565, 134338658, 134970720, 135605431, 136292137, 137006791, 141968478
|
|||
| ChEBI ID |
CHEBI:16294
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Antagonist | [2], [3] |
| Glutamate receptor AMPA (GRIA) | Target Info | Agonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79. | |||
| REF 2 | DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. | |||
| REF 3 | Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology. 1989 Dec;28(12):1317-23. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.