Drug Information
Drug General Information | Top | |||
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Drug ID |
D0WT5D
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Former ID |
DIB018112
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Drug Name |
(S)-EF-1520
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Synonyms |
(S)-EF-1520; GTPL6513
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C22H26N2O2S2
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Canonical SMILES |
CC1=C(SC=C1)C(=CCCN(C)C2CCCC3=C2C(=O)NO3)C4=C(C=CS4)C
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InChI |
1S/C22H26N2O2S2/c1-14-9-12-27-20(14)16(21-15(2)10-13-28-21)6-5-11-24(3)17-7-4-8-18-19(17)22(25)23-26-18/h6,9-10,12-13,17H,4-5,7-8,11H2,1-3H3,(H,23,25)/t17-/m0/s1
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InChIKey |
CUESOMOCKVRNIW-KRWDZBQOSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | GABA transporter GAT-1 (SLC6A1) | Target Info | Inhibitor | [2] |
Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) | Target Info | Inhibitor | [3] | |
KEGG Pathway | GABAergic synapse | |||
Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
WikiPathways | Monoamine Transport | |||
NRF2 pathway |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6513). | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 929). | |||
REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 932). |
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