Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0WY5Q
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| Former ID |
DIB002950
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| Drug Name |
Rivastigmine
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| Synonyms |
Rivastigmine (transdermal patch)
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Approved | [1], [2] | |
| Company |
Samyang Corp
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| Structure |
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Download2D MOL |
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| Formula |
C14H22N2O2
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| Canonical SMILES |
CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
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| InChI |
1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1
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| InChIKey |
XSVMFMHYUFZWBK-NSHDSACASA-N
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| CAS Number |
CAS 123441-03-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13930, 7980526, 8199304, 14774320, 15122215, 17397908, 43133576, 46507452, 46511221, 46512204, 48416523, 50064280, 50112784, 50261541, 57332462, 92308834, 93166474, 99246076, 103188932, 104368723, 117695400, 126617420, 126651532, 126664492, 129736061, 131345536, 134337471, 135035468, 135668168, 136947990, 137003256, 137550927, 152035753, 160647611, 160964326, 162210022, 163621046, 164825741, 174006853, 174531833, 175268589, 175605731, 175612189, 176484202, 178103215, 179116882, 184546191, 185974791, 196106102, 223368211
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| ChEBI ID |
CHEBI:8874
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| ADReCS Drug ID | BADD_D01955 ; BADD_D01956 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholinesterase (AChE) | Target Info | Modulator | [3] |
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Cholinergic synapse | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Acetylcholine Synthesis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6602). | |||
| REF 2 | ClinicalTrials.gov (NCT00948766) Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44. U.S. National Institutes of Health. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465). | |||
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