Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X0WU
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| Former ID |
DIB011114
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| Drug Name |
Tolperisone
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| Synonyms |
Agileo; Viveo; AV-650; SPH-3047; Tolperisone (controlled-release); Tolperisone (controlled-release), Sanochemia; Tolperisone (controlled-release), Sanochemia/Avigen
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| Drug Type |
Small molecular drug
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| Indication | Muscle spasm [ICD-11: MB47.3; ICD-10: R25.2] | Approved | [1] | |
| Company |
Sanochemia Pharmazeutika AG
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H23NO
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| Canonical SMILES |
CC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2
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| InChI |
1S/C16H23NO/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17/h6-9,14H,3-5,10-12H2,1-2H3
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| InChIKey |
FSKFPVLPFLJRQB-UHFFFAOYSA-N
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| CAS Number |
CAS 728-88-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:93835
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated calcium channel (Cav) | Target Info | Modulator | [2], [3] |
| Voltage-gated sodium channel alpha Nav1.9 (SCN11A) | Target Info | Modulator | [1], [2] | |
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. | |||
| REF 3 | Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34. | |||
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