Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X3CD
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| Former ID |
DNCL002517
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| Drug Name |
Thiarabine
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| Synonyms |
THIARABINE; 26599-17-7; UNII-YCO2764D5Z; YCO2764D5Z; Thio-Cytarabine; 4'-Thioaracytidine; 4'-Thio-ara-C; T-araC; OSI 7836; 4'-Thio-1- beta-D-arabinofuranosylcytosine; cytidine, 4'-thio-arabino-; AC1L524F; SCHEMBL1955046; CHEMBL1631221; 4-Amino-1-(4-thio-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone; ZINC17378676; 2(1H)-Pyrimidinone, 4-amino-1-(4-thio-beta-D-arabinofuranosyl)-; SB18955; KB-81109; HY-16496; LS-193593; CS-0006364
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
Access Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H13N3O4S
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| Canonical SMILES |
C1=CN(C(=O)N=C1N)C2C(C(C(S2)CO)O)O
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| InChI |
1S/C9H13N3O4S/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
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| InChIKey |
GAKJJSAXUFZQTL-CCXZUQQUSA-N
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| CAS Number |
CAS 26599-17-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01139151) 4'-Thio-araC (Thiarabine) in Advanced Hematologic Malignancies. U.S. National Institutes of Health. | |||
| REF 2 | Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer. Chem Rev. 2009 July; 109(7): 2880-2893. | |||
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