Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X4EV
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| Former ID |
DNC003706
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| Drug Name |
8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine
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| Synonyms |
CHEMBL134057; 8-chloro-1,2,3,4-tetrahydroacridin-9-amine; 122994-74-5; 8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine; SCHEMBL9584574; MolPort-039-242-295; ZINC27416388; BDBM50279984; AKOS033887449; 9-Amino-8-chloro-1,2,3,4-tetrahydro-acridinium
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H13ClN2
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| Canonical SMILES |
C1CCC2=NC3=C(C(=CC=C3)Cl)C(=C2C1)N
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| InChI |
1S/C13H13ClN2/c14-9-5-3-7-11-12(9)13(15)8-4-1-2-6-10(8)16-11/h3,5,7H,1-2,4,6H2,(H2,15,16)
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| InChIKey |
KVGMGGLTJLJDFE-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Cholinergic synapse | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Acetylcholine Synthesis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex ) derivaties, Bioorg. Med. Chem. Lett. 2(8):861-864 (1992). | |||
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